The England defender pulled up holding his hamstring half an hour into Saturday’s 2-0 win over Leicester City at the King Power Stadium and was replaced by Eliaquim Mangala.
Speaking in his post-match news conference, Guardiola confirmed that the 23-year-old could be out of action for the rest of the year and miss games against Manchester United and Tottenham.
“It is unfortunate for us and for John and I think he might be out for six weeks with that type of injury,” Guardiola said.
“We don’t have a lot of central defenders, but the spirit in the team – and with all the players – is good so we are going to find a solution.”
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